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arbcombo -- Peripheral Blood Gene Expression in Subjects with Coronary Artery Disease and Exposure to Particulate Air Pollutants

Posted: 16 Apr 2014 16:04:24
Presentation is available for downloading!

“Peripheral Blood Gene Expression in Subjects with
Coronary Artery Disease and Exposure to Particulate
Air Pollutant Components and Size Fractions”. 


Ralph J. Delfino, M.D., Ph.D.
University of California, Irvine

Thursday, April 17, 2014 1:30 pm, PDT (WEBCAST)
Sierra Hearing Room, 2nd Floor, Cal/EPA Building
1001 I Street, Sacramento, California

Cardiovascular disease outcomes have been associated with
exposure to ambient particulate matter (PM) air pollution in many
epidemiological studies. Experimental studies have revealed
changes in the expression of key genes with exposure to air
pollution from fossil fuel combustion. We hypothesized that blood
cell gene expression levels along biological pathways relevant to
cardiovascular outcomes would be associated with traffic-related
air pollutant exposures in elderly subjects with coronary artery
disease living in the Los Angeles Air basin.

In the present study data were collected in a cohort panel study
funded by National Institute of Health (NIH), National Institute
of Environmental Health Sciences (NIEHS). Overall, the results
obtained in this study support our hypothesis that
traffic-related air pollutant exposures affect the expression of
genes in pathways that are important to adverse cardiovascular

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