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This page updated March 17, 2004.
| This study is an epidemiological study of the acute respiratory health effects
of air pollution, particularly air toxics, on children with asthma. Twenty-six asthmatic Hispanic school children
residing in Eastern Los Angeles participated in the study during the winter of 1999-2000. The study was
co-sponsored by the California Air Resources Board and the South Coast Air Quality Management District and conducted
by investigators at the University of California, Irvine. |
| Importance of the Study |
- The information gathered in this study provides insight regarding the
measurement methods needed to assess personal Volatile Organic Compound (VOC) exposures and doses in
children.
- The association between exposure to VOCs and asthma symptoms is largely
unknown. This is one of the first epidemiological studies to evaluate the association between exposure
to VOCs and other criteria air pollutants and acute health effects in asthmatic children.
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| Study Location |
| This study took place in the Huntington Park region of Eastern Los Angeles.
The investigators made use of two outdoor air toxics monitors operated by the South Coast Air Quality
Management District (highlighted in yellow). |
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Please click on the map for a
larger view of the Delfino Study Area.
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| The information gathered by the study. |
| The study consisted of a variety of measurements taken daily over the course
of about two months. All subjects recorded daily health outcomes (whether or not they had an asthma episode), where
and how much time they spent in different locations (for example, time spent in the car
on the way to school) and peak expiratory flow of the lungs. VOC exposure was measured using breath samples
and personal, indoor home and outdoor stationary site VOC samplers. VOCs measured included: 1,1-dichloroethane,
benzene, carbon tetrachloride, chloroform, styrene, tetrachloroethylene, toluene, m,p-xylene, o-dichlorobenzene, o-xylene
and p-dichlorobenzene. |
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| Important Findings |
- Ambient VOCs (benzene, ethylbenzene, tetrachloroethylene and m,p-xylene) showed associations
with symptoms.
- Criteria pollutants, including ambient ozone, nitrogen dioxide, sulfur
dioxide and particulate matter (PM10) showed significant associations with asthma symptoms.
- Organic carbon and elemental carbon also showed significant associations
with symptoms.
- An association was seen between bothersome asthma symptoms and both
breath and ambient concentrations of benzene.
- Personal exposures and indoor concentrations were correlated for most
VOCs.
- Breath VOC concentrations did not correlate with outdoor VOC concentrations
(except for benzene and m,p-xylene).
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| The final report from this study titled "Evaluation of Health Effects of Toxic Air Pollutants in a Southern California
Community: A Pilot Study" can be found here. |
| In addition to the final report, two peer review articles have been published
on the study, Delfino RJ, et al. Asthma symptoms in Hispanic children and daily ambient exposures to
toxic and criteria air pollutants. Environmental Health Perspectives 111:647-656 (2003) and Delfino RJ, et
al. Respiratory symptoms and peak expiatory flow in children with asthma in relation to volatile organic compounds
in exhaled breath and ambient air. Journal of Exposure Analysis and Environmental Epidemiology 13:348-363
(2003). |
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For more information, please email Barbara Weller or call 1(916)324-4816.
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Research Activities
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