ARB Research Seminar
This page updated June 19, 2013
Research Progress of the Southern California Particle Center Health and Mechanism Studies
John R. Froines, Ph.D., Director, Southern California Particle Center (SCPC)
February 13, 2007
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA
This seminar will address selected research conducted by the Southern California Particle Center (SCPC). The SCPC was begun approximately eight years ago through a grant from the California Air Resources Board to develop new innovative techniques for concentrated and mobile airborne particulate matter (PM) collection and application to studies on chemical toxicology, in vitro and in vivo assays, and human clinical studies. A focus has been on the physical/chemical characterization of PM from a range of sources with particular emphasis on varying size ranges and composition.
This seminar will also address progress on the development of assays for the analysis of PM toxicity in relation to size and composition in relation to consideration of determination of the underlying mechanisms for PM toxicity and health effects. The assays include determination of redox activity including quantitative determination of hydroxyl radical, irreversible electrophilic chemistry and the assessment of signal transduction pathways leading to exacerbation of asthma. We shall address progress on the PM characteristics responsible for pathphysiologic effects increasing or exacerbating the risk of atherosclerosis. We shall report on in vivo studies that have used animal models to study the impact of freeway generated PM on adjuvant effects in allergic airway disease as well as studies investigating freeway sources in relation to changes in cardiovascular endpoints as well as inflammatory responses. The implications of these findings will be discussed in relation to the mechanism associated with PM exposure, but the role of vapor phase co-pollutants will also be examined.
John R. Froines, Ph.D., is the Director of the UCLA Center for Occupational and Environmental Health. Dr. Froines leads a multidisciplinary Center comprised of the UCLA schools of Public Health, Medicine, and Nursing. Dr. Froines' air pollution related research includes the health effects of particulate matter in the ambient environment, lung cancer and non-cancer health effects attributable to air pollution, and the biochemical mechanism of the toxicity of air contaminants. Dr. Froines directs the Southern California Particle Center, a major research center devoted to studying the effects of particulate matter on human health.
Dr. Froines is Director of the NIH Fogarty's UCLA Program in Occupational and Environmental Health and he is Associate Director of the NIEHS Southern California Environmental Health Sciences Center. In addition to his research on air pollution he has conducted research on the carcinogenicity of arsenic, beryllium and chromium during the past decade. In the former case he has focused on the genetic determinants of the mechanism of arsenic related systemic cancers. He has also conducted extensive research on pesticide exposure in Mexico. He has served on the National Toxicology Board of Scientific Counselors as Chair of the Carcinogen Subcommittee. Dr. Froines is the chairman of the State of California 's Scientific Review Panel on Toxic Air Contaminants where he is charged with reviewing data on proposed toxic air contaminants to ensure the appropriate applications of science and risk assessment.
Dr. Froines received his B.S. in Chemistry from the University of California at Berkeley in 1963. He received his M.S. (in 1964) and Ph.D. (in 1966) in Physical-Organic Chemistry from Yale University. Dr. Froines was a NIH postdoctoral fellow with Nobel Laureate, Sir George Porter at the Royal Institution of Great Britain. From 1974 to 1977, he was the Director of the Occupational and Radiological Health Division of the Vermont Department of Health and the Director of Occupational Lung Disease at the Vermont Lung Center. Dr. Froines was the Director of Toxic Substances Standards at Occupational Safety and Health Administration from 1977 to 1979. From 1979 to 1981, he was the Deputy Director of the National Institute of Occupational Safety and Health. In 1981, Dr. Froines was recruited to the UCLA School of Public Health and from 1991 to 1998 he was the Chair of the Department of Environmental Health Sciences.