Research Progress of the Southern California Particle
Center: Health and Mechanism Studies
This page finalized January 24, 2007.
Chair's Air Pollution Seminar
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Tuesday, February
13, 2007
1:30 p.m. - 3:30 p.m.
Sierra Hearing Room, Second Floor
1001 I Street, Sacramento
This
event is being Webcast, click here to view.
Webcast viewers: Please send your
questions during broadcast to: sierrarm@calepa.ca.gov.
Presentation
is available at this link.
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Research Progress
of the
Southern California Particle Center:
Health and Mechanism Studies
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John R. Froines, Ph.D.
Director, Southern California Particle Center (SCPC)
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This seminar will address selected research conducted
by the Southern California Particle Center (SCPC). The SCPC was begun approximately eight years ago through a grant
from the California Air Resources Board to develop new innovative techniques for concentrated and mobile airborne
particulate matter (PM) collection and application to studies on chemical toxicology, in vitro and in vivo assays,
and human clinical studies. A focus has been on the physical/chemical characterization of PM from a range of sources
with particular emphasis on varying size ranges and composition.
This seminar will also address progress on the development of assays for the analysis of PM toxicity in relation
to size and composition in relation to consideration of determination of the underlying mechanisms for PM toxicity
and health effects. The assays include determination of redox activity including quantitative determination of
hydroxyl radical, irreversible electrophilic chemistry and the assessment of signal transduction pathways leading
to exacerbation of asthma. We shall address progress on the PM characteristics responsible for pathphysiologic
effects increasing or exacerbating the risk of atherosclerosis. We shall report on in vivo studies that have used
animal models to study the impact of freeway generated PM on adjuvant effects in allergic airway disease as well
as studies investigating freeway sources in relation to changes in cardiovascular endpoints as well as inflammatory
responses. The implications of these findings will be discussed in relation to the mechanism associated with PM
exposure, but the role of vapor phase co-pollutants will also be examined. |
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John R. Froines, Ph.D., is the Director of the UCLA Center for Occupational and
Environmental Health. Dr. Froines leads a multidisciplinary Center comprised of the UCLA schools of Public Health,
Medicine, and Nursing. Dr. Froines' air pollution related research includes the health effects of particulate matter
in the ambient environment, lung cancer and non-cancer health effects attributable to air pollution, and the biochemical
mechanism of the toxicity of air contaminants. Dr. Froines directs the Southern California Particle Center, a major
research center devoted to studying the effects of particulate matter on human health.
Dr. Froines is Director of the NIH Fogarty's UCLA Program in Occupational and Environmental Health and he is Associate
Director of the NIEHS Southern California Environmental Health Sciences Center. In addition to his research on
air pollution he has conducted research on the carcinogenicity of arsenic, beryllium and chromium during the past
decade. In the former case he has focused on the genetic determinants of the mechanism of arsenic related systemic
cancers. He has also conducted extensive research on pesticide exposure in Mexico. He has served on the National
Toxicology Board of Scientific Counselors as Chair of the Carcinogen Subcommittee. Dr. Froines is the chairman
of the State of California 's Scientific Review Panel on Toxic Air Contaminants where he is charged with reviewing
data on proposed toxic air contaminants to ensure the appropriate applications of science and risk assessment.
Dr. Froines received his B.S. in Chemistry from the University of California at Berkeley in 1963. He received his
M.S. (in 1964) and Ph.D. (in 1966) in Physical-Organic Chemistry from Yale University. Dr. Froines was a NIH postdoctoral
fellow with Nobel Laureate, Sir George Porter at the Royal Institution of Great Britain. From 1974 to 1977, he
was the Director of the Occupational and Radiological Health Division of the Vermont Department of Health and the
Director of Occupational Lung Disease at the Vermont Lung Center. Dr. Froines was the Director of Toxic Substances
Standards at Occupational Safety and Health Administration from 1977 to 1979. From 1979 to 1981, he was the Deputy
Director of the National Institute of Occupational Safety and Health. In 1981, Dr. Froines was recruited to the
UCLA School of Public Health and from 1991 to 1998 he was the Chair of the Department of Environmental Health Sciences. |
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For more information on this
Seminar please contact:
Peter Mathews at (916) 323-8711 or send email to: pmathews@arb.ca.gov
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For a complete listing of
the ARB Chairman's Series and the related documentation for each one of the series please check this page
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Note: for a print friendly
version of this page please click on the "Print Friendly" option at the very top of this page.
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Main Seminar Series Page
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Research
Activities
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