ARB Research Seminar
This page updated June 19, 2013
Inflammatory and Cardiovascular Responses to Inhaled Fine Particles
Dr. Michael T. Kleinman, Department of Community and Environmental Medicine, University of California, Irvine
June 17, 2004
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA
- John Balmes, M.D., Mechanisms of Particulate Toxicity: An Overview
- Colin Solomon, Ph.D., Health Effects in Susceptible Humans
- Karron Power, M.D., Heart Rate Variability Following Controlled Exposure to Particles and Ozone in Asthmatic Individuals
- Kent Pinkerton, Ph.D., Effects on the Respiratory System of Sensitive Animals and Asthmatic Humans
This project examined the effects of PM exposure in senescent (elderly) rats, using a laboratory-generated mixture of ammonium nitrate and elemental carbon (carbon black). Senescent rats exhibited changes in blood pressure and heart rate variability that were consistent with an adverse effect of PM on the heart. Humans and rats, exposed under similar conditions, both exhibited increased activation of macrophages. The results provided evidence of decreased heart rate variability after the exposures. This effect was also noted in the work conducted at UCSF by the previous speakers.
Michael T. Kleinman received his Ph.D. in environmental health sciences from New York University. He is a professor and Associate Director of the Air Pollution Health Effects Laboratory in the Department of Community and Environmental Medicine at University of California at Irvine. He currently serves as the Chair of the California Air Quality Advisory Committee and is a consultant to the U.S. EPA Science Advisory Board. Dr. Kleinman studies the health effects of exposures to environmental contaminants found in the ambient air.