ARB Research Seminar
This page updated June 19, 2013
Toxicity of Source-Oriented Ambient Submicron Particulate Matter
Anthony S. Wexler, Ph.D., Civil and Environmental Engineering and Department of Land, Air, and Water Resources and Director, Air Quality Research Center and Crocker Nuclear Laboratory, University of California, Davis, Kent Pinkerton, Ph.D., Department of Pediatrics, School of Medicine, University of California, Davis, and Keith Bein, Ph.D., Air Quality Research Center and Crocker Nuclear Laboratory
February 19, 2013
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA
Evidence from the scientific literature has shown that exposure to
ambient particulate matter (PM) can be associated with premature death
and hospitalization. However, it is unclear which components
are the most responsible for the adverse health effects, since ambient
PM is mixture of components derived from a wide range of sources and
from atmospheric processes that may alter toxicity. The main goal of
this study was to examine toxicity characteristics of PM or PM
components derived from different source categories and atmospheric
processes. PM samples were collected and concentrated based on source-
and atmospheric process-related chemical compositions during two
seasons (winter and summer) and at two size points (ultrafine and
submicron fine). Mice were then exposed to the isolated PM samples and
studied for possible toxicity. The results showed that among summer PM
samples those containing metals or originating from local vehicular
emissions had the higher biological responses. Among the
winter samples, highly processed regional background PM, PM from
nighttime inversions, or PM from local vehicular emissions
had higher biological responses. In addition,
ultrafine PM was found to have higher biological responses than
submicron fine PM on a per mass basis.
This study was funded jointly by the Air Resources Board and the Electric Power Research Institute.
Anthony Wexler, Ph.D., is a Professor of
Mechanical and Aerospace Engineering, Civil and Environmental
Engineering, and Land, Air and Water Resources. Dr. Wexler is also the
Director of the Air Quality Research Center and Crocker Nuclear
Laboratory. He is the former president of the American Association for
Aerosol Research was the Director of USEPA’s San Joaquin Valley Aerosol
Health Effects Research Center (SAHERC). He currently on editorial
board of Atmospheric Environment.
Kent Pinkerton, Ph.D., is a Professor of Pediatrics in the School of Medicine and Professor of Anatomy, Physiology and Cell Biology in the School of Veterinary Medicine at the University of California, Davis. Dr. Pinkerton is Director of the Center for Health and the Environment and Co-Director of the Western Center for Agricultural Health and Safety at UC Davis. Dr. Pinkerton was the co-director of the SAHERC at UC Davis and served as Chair of the Environmental and Occupational Health Assembly and Chair of the Environmental Health Policy Committee for the American Thoracic Society. Professor Pinkerton currently serves on the editorial board of Inhalation Toxicology.
Keith Bein, Ph.D., is an Assistant Research Scientist at the Air Quality Research Center and Crocker Nuclear Laboratory and a member of the Research Faculty at the Center for Health and the Environment at the University of California, Davis.