Project at a Glance
Project Status: complete
Title: Effect of pollutant exposure ambient air in childhood and adulthood.
Principal Investigator / Author(s): Wegman, David H
Contract Number: A4-068-33
Research Program Area: Health & Exposure
Topic Areas: Health Effects of Air Pollution
This study explored multivariate modeling to describe the relationship between respiratory health and ambient air pollution in three Los Angeles communities using data of respiratory symptoms and pulmonary function collected for the UCLA Population Studies of Chronic Obstructive Respiratory Disease (CORD). Log linear analysis and expert judgement were used to select outcome measures. The modeling approach included linear and logistic regression analysis and focused on adult non-commuting females whose ambient air exposures were best represented by air quality monitoring stations in the community of residence. A model was also developed for use in calculating samples sizes necessary for such duties. Estimates indicated that a small number of subjects was sufficient to identify differences in FEV1 or FVC equivalent to a cigarette smoking effect.
FEV1, FEV1/FVC, and delta N2 were selected as outcome measures. Multivariate analysis did not provide a clear model which improved on earlier analyses. Effects of birthplace or current abnormal respiratory health as indicators of potential "susceptibility" to air pollution were not identified. These results were judged indicative of limits in the data available for estimating ambient air exposures for individual study subjects.
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