Research Projects

Epidemiological and animal studies have shown an association between near-roadway exposure to particulate matter and adverse health effects. This study will address the question of whether adverse effects are due to specific classes of reactive organic compounds on the particles. Ultrafine particles will be concentrated and heated to remove the semi-volatile organic compounds that may be responsible for the adverse health affects. Mice with elevated risk of coronary artery disease will be exposed to particles at a site near a roadway with or without semi-volatile organics. If successful, this project could improve the understanding of the mechanism of toxic action of freshly emitted combustion particles and identify fractions of ultrafine particles causally related to health effects. This information will also aid regulators and planners in developing air quality regulations to better protect the health of California residents.