Research Projects

Project at a Glance

Project Status: active

Title: Central nervous system effects of ambient particulate matter: the role of oxidative stress and inflammation

Principal Investigator / Author(s): Kleinman, Michael

Contractor: UC Irvine

Contract Number: 08-306


Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution


Research Summary:

Numerous epidemiological and toxicological studies have demonstrated that exposure to ambient PM is associated with increased cardiopulmonary morbidity and mortality; however, little is known about the effects of PM exposure on other organ systems. Several animal exposure studies have shown that inhaled particles can be transported to the brain, and that exposure to concentrated ambient particles (CAP) is associated with increased signaling pathway activity associated with inflammatory responses in the brain, as well as increased levels of biomarkers of oxidative stress and tissue injury. The objectives of the proposed study, as stated in this revised proposal, are to examine the potential for CAPs exposure to induce adverse effects on the central nervous system (CNS) and to determine the role of inflammation and/or oxidative stress in bringing about these effects. Results of this study could provide an improved understanding of mechanisms of PM action on the CNS and insight into whether ambient aerosol exposure induces neurological effects. Findings from this research could also help determine how specific chemical constituents of the aerosol are associated with health effects. This information could be of value in setting ambient air quality standards and developing air quality regulations to better protect the health of California residents.


 

For questions regarding research reports, contact: Heather Choi at (916) 322-3893

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