Project at a Glance
Project Status: active
Title: Probing the instrinsic ability of particles to generate reactive oxygen species and the effect of physiologically relevant solutes
Principal Investigator / Author(s): Paulson, Suzanne E.
Contractor: UC Los Angeles
Contract Number: 10-314
Research Program Area: Atmospheric Processes
Topic Areas: Chemistry & Reactivity
Determining the ‘causative agents’ in PM that are responsible for damaging health is the subject of increasing research activity but many questions remain. A scientific consensus has emerged that oxidative stress mediated by reactive oxygen species (ROS) is a major mechanism by which PM contributes to illnesses and mortality. Freshly collected ambient particles are able to generate significant amounts of ROS. This work is aimed at understanding the components in PM responsible for ROS formation under physiological conditions and the role of two important ROS: hydrogen peroxide (H2O2) and hydroxyl radical (OH). Measurements of aerosols in the field will be complemented by laboratory studies of ROS generation by metals and organics in PM, as well as source aerosols such as diesel exhaust. The detailed analysis of organics and metals from field samples will allow for the attribution of those components most responsible for ROS activity to their sources. This will enable the development of PM controls that target the sources that are most responsible for the toxicity of PM.
For questions regarding this research project, including available data and progress status, contact: Heather Choi at (916) 322-3893
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