Research Projects

Project at a Glance

Project Status: active

Title: Cardiovascular Effects of Multipollutant Exposure: Mechanisms and Interactions

Principal Investigator / Author(s): Michael Kleinman

Contractor: UC Irvine

Contract Number: 13-309


Research Program Area: Health & Exposure

Topic Areas: Ambient Air Quality Stds, Health Effects of Air Pollution


Research Summary:

The objective of this study is to investigate the atherosclerotic potential of ambient PM2.5 from the Irvine, California area. Both intact particles and particles denuded of the semi volatile constituents of PM2.5 will be used with and without concurrent exposure to ozone in a mouse model of atherosclerosis. The principal goals are to elucidate the role of the semi-volatile components of PM2.5 and ozone in the progression of atherosclerosis, and the extent to which concomitant ozone exposure interacts with disease progression.


 

For questions regarding research reports, contact: Heather Choi at (916) 322-3893

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