Research Projects

Project at a Glance

Project Status: active

Title: Co-Exposure to PM and O-3: Pulmonary C Fiber Platelet Activation in Decreased HRV

Principal Investigator / Author(s): Tablin, Fern

Contractor: UC Davis

Contract Number: 13-311


Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution


Research Summary:

People are routinely exposed to ambient air that contains a complex mixture of air pollutants. Fine particulate matter (PM2.5) and ozone (O3) appear to be responsible for the majority of serious health effects related to air pollution exposure, although little is known about how these pollutants cause adverse health effects, or whether or not they have interactive or synergistic effects on health endpoints. The objective of this study is to examine a hypothesized mechanistic pathway for the cardiovascular effects of ozone and PM2.5, and to examine whether the effects of co exposure to these pollutants are additive or synergistic in laboratory animals. Normal and spontaneously hypertensive rats with implanted telemetry units that record the electrocardiogram and breathing pattern will be exposed for six hours to filtered air, and PM2.5 and O3, alone and in combination. At the end of exposure, multiple endpoints related to platelet, vascular endothelial, heart rate variability, cardiac arrhythmia, and nervous system function will be evaluated to assess the contribution of each mechanistic pathway to the health effects observed. Analyses will compare responses to ozone alone and PM2.5 alone to responses to filtered air and the combined exposure (ozone plus PM2.5).


 

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