ARB Research Seminar

This page updated June 19, 2013

Inflammatory and Cardiovascular Responses to Inhaled Fine Particles

Dr. Michael T. Kleinman, Department of Community and Environmental Medicine, University of California, Irvine

June 17, 2004
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA

Research Project

Other seminars from the June 17, 2004, Mechanisms of Particulate Toxicity series:


This project examined the effects of PM exposure in senescent (elderly) rats, using a laboratory-generated mixture of ammonium nitrate and elemental carbon (carbon black). Senescent rats exhibited changes in blood pressure and heart rate variability that were consistent with an adverse effect of PM on the heart. Humans and rats, exposed under similar conditions, both exhibited increased activation of macrophages. The results provided evidence of decreased heart rate variability after the exposures. This effect was also noted in the work conducted at UCSF by the previous speakers.

Speaker Biography

Michael T. Kleinman received his Ph.D. in environmental health sciences from New York University. He is a professor and Associate Director of the Air Pollution Health Effects Laboratory in the Department of Community and Environmental Medicine at University of California at Irvine. He currently serves as the Chair of the California Air Quality Advisory Committee and is a consultant to the U.S. EPA Science Advisory Board. Dr. Kleinman studies the health effects of exposures to environmental contaminants found in the ambient air.

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