ARB Research Seminar

This page updated June 19, 2013

Effects on the Respiratory System of Sensitive Animals and Asthmatic Humans

Dr. Kent Pinkerton, School of Veterinary Medicine, University of California, Davis

June 17, 2004
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA

Research Project

Other seminars from the June 17, 2004, Mechanisms of Particulate Toxicity series:


This project examined rats that were sensitized to ovalbumin (egg whites) prior to PM exposure, in order to develop an animal model that physiologically mimics asthmatic conditions found in humans. The PM exposures in these rats led to effects such as altered airway epithelial cells and increased airway inflammation. This project also involved the assay of cellular endpoints in human lung tissue samples obtained from asthmatics exposed to PM at UCSF. Based on these assays, PM exposure led to detectable changes in levels of cytokine expression, which help generate immune responses.

Speaker Biography

Kent Pinkerton received his Ph.D. in pathology from Duke University Medical Center. He is a professor in the Department of Anatomy, Physiology, and Cell Biology in the School of Veterinary Medicine at the University of California at Davis, where he serves as director of the Center for Health and the Environment. He has been studying the effects of air pollutants on lung structure and function, the interaction of gases and airborne particles within specific sites and cell populations of the lungs, and the effects of environmental tobacco smoke and combustion emissions on lung growth and development.

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for the seminars please view the Main Seminars web page