ARB Research Seminar

This page updated May 13, 2015

Health Effects of Central Valley Particulate Matter

Photo of Kent Pinkerton

Kent Pinkerton

Photo of Keith Bein

Keith Bein

Photo of Fern Tablin

Fern Tablin

Kent Pinkerton, Ph.D., Department of Pediatrics, School of Medicine; Keith Bein, Ph.D., Air Quality Research Center and Crocker Nuclear Laboratory; and Fern Tablin, V.M.D., Ph.D., School of Veterinary Medicine, University of California, Davis

May 27, 2015
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA

Research Project


The overall objective of this work was to better elucidate the toxic and inflammatory potential of urban and rural particulate matter (PM) from the Central Valley on a suite of pulmonary, vascular and systemic endpoints in a mouse model. Specifically, mice received one intratrachael aspiration exposure to PM2.5, and effects were evaluated at post-exposure times of 1, 2, and 4 days to explore the temporal nature of different biological responses. PM2.5 samples were collected in a rural part of Davis that is surrounded by agricultural land and an urban part of downtown Sacramento near a major freeway interchange in order to obtain a comparison between the health effects elicited by PM that has different source mixtures.

Sufficient PM was collected during a single winter collection campaign to allow animal exposures and chemical analysis using the same PM sampling filter. The results demonstrate (1) that the method of extraction of PM from the filter or impactor substrate has a substantial effect on the health effects elicited and the dose-response relationship; (2) some of the endpoints, especially the pulmonary ones, responded acutely to the PM, at 1 or 2 days post administration while other endpoints, especially systemic ones, responded at longer lag times, in agreement with epidemiological studies on cardiovascular responses to PM. The results have implications for design of future research studies, and help to explain some of the inconsistencies noted in previously published research.

Speaker Biography

Kent E. Pinkerton, Ph.D., is Professor and Director, Center for Health and the Environment, University of California, Davis. Dr. Pinkerton's research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development. Profesor Pinkerton serves as the Associate Director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. Dr. Pinkerson also serves as the Associate Director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting.

Keith J Bein, Ph.D., is Research Scientist at the Air Quality Research Center and Crocker Nuclear Laboratory and a member of the Research Faculty at the Center for Health and the Environment at the University of California, Davis. Dr. Bein's primary research interests include air quality dynamics, air pollution regulation and mitigation research, climate change, environmental health and health disparities research, design and development of air quality monitoring and sampling instrumentation, systems modeling and data analysis techniques. He received B.S. degrees in Physics and Chemistry from California State Univeristy, Chico and a Ph.D. in Atmospheric Sciences from UC Davis.

Fern Tablin, V.M.D, Ph.D., is Professor at the School of Veterinary Medicine, University of California, Davis. Dr. Tablin currently directs a translational research program that examines how environmental air pollution affects hemostasis and coagulation in human and animal health. The majority of Dr. Tablin's platelet studies focus on animal models of disease and their response to PM. Professor Tablin's research group has shown that exposure to PM results in up-regulation of platelets i.e. "platelet priming", such that these cells are more sensitive to agonist and more likely to develop micro-thrombi in the systemic circulation leading to increased incidence of cardiac events. Dr. Fern Tablin received her VMD and Ph.D. degrees from the University of Pennsylvania.

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