Project at a Glance

Title: Combined Exposures to Ultrafine Particulate Matter and Ozone: Characterization of Particular Deposition, Pulmonary Oxidant Stress and Myocardial Injury

Principal Investigator / Author(s): Schelegle, Edward

Contractor: UC Davis

Contract Number: 17RD011

Research Program Area: Health & Exposure

Topic Areas: Ambient Air Quality Standards, Health Effects of Air Pollution, Toxic Air Contaminants

Research Summary:

Epidemiologic research has suggested a statistical correlation between exposure to PM and ozone (O3), and adverse health effects. Findings obtained in the previously recent ARB funded investigation, "Co-Exposure to PM and O3: Pulmonary C Fiber Platelet Activation in Decreased HRV," demonstrated that exposure to a combination of ultrafine particulate matter (UFPM) and ozone increases the biological potency of exposure, resulting in exaggerated pulmonary and cardiac patho-physiological responses compared to single pollutant exposure in mature normal and spontaneously hypertensive adult rats. This was the first study to provide direct evidence of air pollution exposure-induced myocardial injury in an animal model. The currently proposed study will conduct immunostochemical analysis, immunohistopathological analysis, and UFPM mapping in previously collected pulmonary and myocardial tissue samples from the aforementioned study and is expected to elucidate the mechanistic basis of the increased biological potency resulting from combined acute exposure to UFPM and O3 in rats with and without cardiovascular disease (CVD). This work is critical for improved scientific understanding of the adverse health effects of combined-pollutant exposure and is expected to provide additional guidance and rationale for future regulatory actions regarding multipollutant exposures.

For questions regarding this research project, including available data and progress status, contact: Research Division staff at (916) 445-0753

Stay involved, sign up with CARB's Research Email Distribution List